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I got this cool CD from a gene sequencing startup today.

Sony is repurposing media, as the digital hybrid vehicle transitions to pure code. From music to data to DNA.

Specifically, Sony is entering the bio-research market with their experience and excess capacity in digital discs, with high-aspect ratio wells and posts.

I wondered if these test structures were just a cheap substrate or a spinning media as well. The CD format is used for active fluidics as well: it eliminates pumps and valves, and one can modulate the flow to mixing, reagent and waste chambers at outer regions by varying the speed of rotation.

And I heard an interesting application of these spinning discs today. Prof. Madou at UC Irvine was investigating what happens to life forms when launched into space. He used a worm that activates genes for a fluorescent green protein under stress conditions. He used microfluidic discs spun at various angular velocities and accelerations, and the worms were stressed after some speed threshold. But when he gave them prozac mixed in the food in the wells of the disc, they would stop stressing out, even in the highest of centrifuging velocities. He turned some of his research towards tests for the efficacy of certain drugs.

25 responses to “From Music to Microfluidics”

  1. This is cool. The ability to use materials in many different ways and applying them to new innovations is always important.

  2. That is amazing. Thanks for the description.

  3. What is the vertical scale, into the disk, of these surface features?

  4. Glow worms in space…on Prozac…
    Now I have heard everything…

  5. Jaw dropping amazing.. Some really bright folks out there.

  6. Nice Picture. However, you can see that it is just a mock-up as these channels need to be layed out differently to work with centrifugal force i.e. radial or spiral. You can also see that some of the features go over the edge of the disk. This technology is actually not that new and is termed "lab an a cd" (distinct from lab on a chip). If you want to see a real example of this kind of work visit http://www.gyros.com/en/home/index.html. or search for lab on a cd. Cheers

  7. This is something I have always suspected about Prozac

  8. Thank goodness you’re back to regularly scheduled programming, Steve! 😉 I still have a single raised eyebrow from your previous cat wedding upload.

  9. heh… I was wondering how that might go down… =)

    [http://www.flickr.com/photos/48331433@N05] – secret cocktail for the space program?

    Lab-Boy: Yes, this is an Amic test bed, not meant for spinning.

    [http://www.flickr.com/photos/philatkin] – not sure, but in their ppt, Sony brags about the pit depth of Blue-ray vs CDs as an advantage. They also have nano imprint litho capabilities.

    Sony DACD

  10. Oh, didn’t go down well at all. I am in the minority, but while I love cats (had many growing up and trying to woo a cat for part-time pet for 2 months now), I balked. To put things in context, you’re listed among "Inspirational people" likes on my FB page. The only other person on the list is also a Steve J., only less famous than you. 😉

  11. You could reasonably say prozac helps levitation, if you are being loose with some concepts.

  12. maybe Sony will win this battle… music not much (thanks to Apple)

  13. [http://www.flickr.com/photos/ushwink] I’m still wondering how Steve managed to dress up two cats in heat. I think this must be a first of some sort.

  14. All these German names, you know it must be a good, and with full pdf links ….
    http://www.sensorprod.com/research-articles/white-papers/2011-08...

  15. "Growing Worms in Space
    Changing course drastically, he then shared with the group research that led to a paper he published in the Journal of Genetics last year. The work, originally contracted by NASA, involved spinning tiny worms called C. elegans, which are about 2 millimeters long, onto a compact disc. The worms, which were the only creatures to survive the space shuttle Columbia disaster, provide valuable information on aging and other reactions in space, Madou said, and NASA was looking for ways to grow them in orbit.

    He formatted a CD with separate chambers in which to grow the worms, feed them and eliminate waste material. Spinning the CD creates centrifugal forces which allow fluids to move from one chamber to another. The worms are fed E. coli and when the disc is spun, the waste is eliminated. The discs have room for several distinct colonies, allowing researchers to vary conditions in their experiments. And because they are self-replicating, one worm can generate 1,000 worms in a matter of days.

    An additional experiment involved controlling the revolutions per minute – which on a CD is about 7,000. These revolutions increase the G forces, allowing scientists to study the worms’ genetics and physiology in hyper-gravity. Madou said the worms’ sense of smell, response, appetite, and muscle structure remained intact at 100 Gs. “You can see these are damn strong worms,” he said, displaying his results.

    But researchers determined the worms were accumulating fat, leading to the deduction that they were stressed by the hyper-gravity. Prozac, however, reversed the physiological signs of stress, and because the worms share certain physiological processes with humans, they could be used to study new drugs, Madou concluded." weboflife.nasa.gov/celegans/index.htm

  16. Seems to me we have enough worms right down here…

    Its probably ? $5K a head ( tail ?) to launch them…on CD’s or even freeze dried…
    The whole thing with giving them drugs sounds to me like an over funded research slot…
    At NASA and possibly Pfizer

    (runs and hides)

  17. [http://www.flickr.com/photos/daveh56] Naaahhh. Bring on the mutant PCR template optimized micro fab DADC space worms! mmadou.eng.uci.edu/docs/publications/2011%20Amasia%20Cent…

  18. What was that Churchill quote…?

  19. [http://www.flickr.com/photos/daveh56] We are all worms. But I believe that I am a glow-worm.

  20. I thought I’d let you know I liked your photo so much I’ve added it to my Rap Artist Development page on my website.(The Web’s Largest Learn How Too Rap FREE Guide!!)

    Thanks for the wonderful photo!!

  21. [http://www.flickr.com/photos/82197838@N07] Microfluidics is going to be big in Rap lyrics.
    Spinin rhymes with MY-CROW space worm HOES!

  22. =)))

    CC reuse is like a speakerboxxx full of chocolates; you never know what you’re gonna get

    Screen Shot 2012-07-09 at 9.30.00 AM

  23. [http://www.flickr.com/photos/jurvetson]
    YO, Big cash spin micro worm hoe bitches! Get ’em happy with my Prozack – Keep those micro hoe hands offa my stack!

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