Set and Setting for Psychedelics

From brain imaging of mice on psilocybin, Boris Heifets found no difference in brain activation from changes in the setting (empty cage versus full of toys). But for mice on MDMA, there is a totally different activity profile if they are in a social environment or not.

Boris has found specific neurons that recreate the MDMA experience when activated. Perhaps we could use TMS or tFUS to get the same response?