Deisseroth on Disassociation

Karl Deisseroth gave an update on his work on disassociation (10% incidence and 70% among people with trauma) with a self-portrait by Andy Warhol on the screen. When in a state of induced disassociation (e.g., from ketamine), he finds a 3 Hz rhythm in a part of the Default Mode Network involved with coordinate transformations (aligning the 3D models for ego-centric and allocentric coordinates).

I find this fascinating in light of Jeff Hawkins’ work on the ubiquity of reference frames in cortical columns: Everything we perceive is a constructed reality, a cortical consensus from competing internal models resident in many cortical columns, the amalgam of 1000 brains. Those models are updated by data streaming from the senses. But our reality resides in the models. (link below)