Coronavirus Toy

OK, the placebo plush toy gift for our baby is a bit much.

It looks like IPD’s decorated nanoparticle vaccine… or the spiky coronavirus itself.

I have been brainstorming with David Sinclair (the Harvard Med School Professor who wrote Lifespan and focuses on NAD boosters like NMN) about downstream NAD / sirtuin effects on COVID-19.

The observed age effect is stark: the younger a person is, across the spectrum, the lower the death rate and hospitalization rate. Why?

Looking to NAD-depletion as we age, and exacerbated by inflammation, perhaps it’s ultimately an energy crisis and a loss of NAD + ATP that does us in.

Snips from his recent book, Lifespan:
“NAD boosts the activity of all seven sirtuins. And because NAD is used by over 500 different enzymes, without any NAD, we’d be dead in 30 seconds. NAD acts as a fuel for sirtuins. NAD levels decrease with age throughout the body. Human studies with NAD boosters (NMN and NR) are ongoing. So far, there has been no toxicity, not even a hint of it.” (p.134)

Also: “Most antiviral drugs target specific viral proteins. Consequently, they often work for only one virus, and their efficacy can be compromised by the rapid evolution of resistant variants. There is a need for the identification of host proteins with broad-spectrum antiviral functions, which provide effective targets for therapeutic treatments that limit the evolution of viral resistance. Here, we report that sirtuins present such an opportunity for the development of broad-spectrum antiviral treatments, since our findings highlight these enzymes as ancient defense factors that protect against a variety of viral pathogens.” — Researchgate

I take NMN + TMG in the morning. Sinclair added trimethylglycine (TMG) in a recent podcast. He also mentions not to take NMN or NR at night as they interfere with sleep.

This was an addendum to my prior post on the supplements I am taking.