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She is the brilliant founder of Sirius satellite radio and United Therapeutics (UTHR), and… well, I was excited to meet her once exposed to the mesmerizing NY Magazine biopic: “Martine Rothblatt, the highest-paid female executive in America, was born male. But that is far from the thing that defines her. Just ask her wife. Then ask the robot version of her wife.”

She commented on what Venter calls the “Sarah Palin Project” to humanize a pig so that its heart, lung and kidney could be used for xenotransplant without chronic immunosuppressants: “Even among the conservative transplant surgeons, no one thinks it’s science fiction any more.”

“Although one third of us volunteer as organ donors, and we should, less than 1% of us will die in a way that allows for a transplant.”

Martine owns a pig farm called Revivacor, and predicts that life-saving pig-human transplants will arrive by the end of the decade. In 2013, she got her pilot’s license, so that she might speedily transport pig organs to waiting human patients. She flew in to today’s meeting by helicopter.

I think she won Venter’s heart today with her opening perspective (this being her first SGI board meeting, I had to take a memorial shot): “This is the most important company founded in the 21st century. You are creating new ontologies of life. There has been nothing as important since prokaryotic cells.”

Wow. I want to remember this perspective… and I had to quip that rarely do I hear someone trumping Venter on breathtaking vision.

And at the conclusion of our meeting: “Once in a century do you get a chance to change the history of the world. This is an astonishing opportunity. I’ve never seen anything like it”

Her public company, United Therapeutics has the artistic flair of Hunter S. Thompson, and she just published a new book: Virtually Human: The Promise—and the Peril—of Digital Immortality

More gems from today:

Nobel Laureate Hamilton Smith: “Natural organisms are not fully evolved.”

JCV: “Colbert asked me: How can you hope to improve on what God did? I answered: because we have computers.”

And on a manager’s stumble on JCVI versus SGVI: “Some are Vaccines; some are Venters”

7 responses to “Martine Rothblatt’s first board meeting with Craig Venter”

  1. a surprise birthday cake for fellow board member Alfonso Romo Alfonso Bday cake And we ate some syn food, reconstituted into pork of all things… =) DSC04030

  2. Intrigued by the comment ‘robot version of her wife’ ?

  3. It’s the opening to the NY Magazine article…. More photos from Colbert Wife-and-Robot robots_628 I played with a frubber fem-bot a decade ago: HALLE's Eye

  4. and four months laterCraig Venter on headless humans and predicting your exact face from your DNA Craig has a way with words… “You can’t grow organs outside of the body. DARPA was enamoured with the idea of headless humans a few years back, but we learned that you also need the nervous system for organ development.”

  5. Success! From today’s NPR: “In a major scientific advance, a pig kidney is successfully transplanted into a human. ‘It had absolutely normal function,’ said Dr. Robert Montgomery, who led the surgical team last month at NYU Langone Health. ‘It didn’t have this immediate rejection that we have worried about.’ More than 90,000 people in the U.S. are in line for a kidney transplant. Every day, 12 die while waiting. The advance is a win for Revivicor, a subsidiary of United Therapeutics, the company that engineered the pig and its cousins, a herd of 100 raised in tightly controlled conditions at a facility in Iowa. The pigs lack a gene that produces alpha-gal, the sugar that provokes an immediate attack from the human immune system.”

  6. And today’s NYT: “It was better than I think we even expected,” Dr. Montgomery said. “It just looked like any transplant I’ve ever done from a living donor. A lot of kidneys from deceased people don’t work right away, and take days or weeks to start. This worked immediately.” Genetically engineered pigs “could potentially be a sustainable, renewable source of organs — the solar and wind of organ availability,” Dr. Montgomery said.

    Reactions to the news among transplantation experts ranged from cautiously optimistic to wildly effusive, though all acknowledged the procedure represented a sea change. “This is really cutting-edge translational surgery and transplantation that is on the brink of being able to do it in living human beings,” said Dr. Amy Friedman, a former transplant surgeon and chief medical officer of LiveOnNY, the organ procurement organization in the greater New York area. Dr. Friedman said she envisioned using hearts, livers and other organs grown in pigs, as well. “It’s truly mind-boggling to think of how many transplants we might be able to offer,” she said, adding, “You’d have to breed the pigs, of course.”

    Dr. Montgomery and his team also transplanted the pig’s thymus, a gland that is involved in the immune system, in an effort to ward off immune reactions to the kidney."

  7. And today, a heart transplant in human… fingers crossed for this watershed moment… using a GM-pig heart from Revivicor (Rothblatt’s startup):

    "The pig had 10 genetic modifications. Four genes were knocked out, or inactivated, including one that encodes a molecule that causes an aggressive human rejection response. A growth gene was also inactivated to prevent the pig’s heart from continuing to grow after it was implanted… In addition, six human genes were inserted into the genome of the donor pig — modifications designed to make the porcine organs more tolerable to the human immune system."

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